Welcome to your Introduction, History and development of medicinal chemistry-(201)
Aspirin is introduced by_________in 1889
A compound with high potency but poor oral exposure needs optimization of:
A narrow therapeutic index increases the importance of:
A pharmacophore represents:
Reducing conformational flexibility can sometimes:
A compound is rapidly oxidized at a benzylic position. A medicinal chemist may:
A lead has good target affinity but severe hERG liability. Medicinal chemistry should prioritize:
How many people will be selected for phase III trial?
A target structure reveals an unoccupied lipophilic pocket. A rational modification is:
How many people will be selected for phase I trial?
A compound loses potency after replacing an aromatic ring with a saturated ring. The most likely interpretation is:
A lead compound is best described as:
A para-halogen on an aromatic ring can influence:
Ligand-based drug design can exploit:
Lead optimization aims to improve:
The process of bringing a new pharmaceutical drug to the market once the lead compound has been identified through the process of drug discovery. (From Lead to NDA) is known as
Phase IV trial is also known-
If a substituent increases potency but also increases lipophilicity markedly, the key concern is:
Human micro dosing studies conducted in which clinical phase ?
A bioisosteric replacement is most useful when:
Adding a methyl group near a metabolic oxidation site may:
First hormone epinephrine was synthesized in Year
Bioisosterism is used to:
A structure-based design strategy uses:
Identification of a new chemical entity as a potential therapeutic agent (From Hit to Lead) is known as
Replacing a phenyl ring with a pyridyl ring most directly changes:
Replacing an ester with an amide often tends to:
Single ascending dose studies are done in_____
A compound is active in vitro but inactive in vivo. One possible reason is:
Natural products or derivatives or synthetic substances with good binding ability in Drug discovery is known as
Precision Medicine is an emerging approach depending on-
Two analogues have equal potency, but one has much better selectivity. The preferred lead is generally:
Who is founder of modern medicine?
Compound with good activity and selectivity in screening during drug discovery is known as
A ligand binds well but is poorly soluble. A rational first strategy is:
How many people will be selected for phase II trial?
Which of the following reactions is catalyzed by the enzyme adenylate cyclase?
A stereocenter can affect activity because:
Medicinal chemistry is interdisciplinary because it combines:
High-throughput screening is used to:
Morphine was isolated from opium by-
A carboxylic acid group in many NSAIDs commonly provides:
The main goals of pre-clinical studies
In a classical pharmacophore, a basic nitrogen may represent:
Medicinal chemistry is primarily concerned with:
Quaternization of an amine generally:
A lead series shows a consistent activity trend with para-substituent changes. This can support:
