The primary site of action of thiazide diuretics is:
Which of the following has a ‘self limiting diuretic’ (action of the drug itself causing changes which limit further diuresis) action:
The vasopressin action(s) mediated by V2 receptors include(s):
The following diuretic abolishes the corticomedullary osmotic gradient in the kidney:
Select the diuretic that can cause gynaecomastia, hirsutism and menstrual disturbance as a side effect on long-term use:
Which of the following peptides is a selective vasopressin V2 receptor agonist:
The most appropriate measure to overcome diminished responsiveness to furosemide after its long term use is:
Individual drugs of thiazide and related class of diuretics differ markedly from each other in the following respect?
Aldosterone increases Na+ reabsorption and K+ excretion in the renal collecting duct cells by:
The following is not itself an efficacious diuretic, and is used only as an adjuvant/corrective to other diuretics:
Select the diuretic which is similar in efficacy and pattern of electrolyte excretion to furosemide, but is 40 times more potent dose to dose:
Choose the correct statement about amiloride
Parenteral furosemide is an alternative diuretic to mannitol in the following condition:
Long-term thiazide therapy can cause hyperglycaemia by:
Furosemide acts by inhibiting the following in the renal tubular cell:
The following tissue is most sensitive to vasopressin:
Which of the following is a potassium retaining diuretic:
Thiazide diuretics and furosemide have directionally opposite effect on the net renal excretion of the following substance:
Amiloride has the following effect on urinary cation excretion:
Use of potassium sparing diuretics in patients receiving the following drug needs close monitoring:
Choose the correct statement about osmotic diuretics:
The Na+-Cl– symport in the early distal convoluted tubule of the kidney is inhibited by:
Choose the correct statement about thiazide diuretics:
At equinatriuretic doses which diuretic causes the maximum K+ loss:
The current therapeutic indication of acetazolamide is:
