Welcome to your Introduction, History and development of medicinal chemistry-(201)
Human micro dosing studies conducted in which clinical phase ?
First hormone epinephrine was synthesized in Year
Natural products or derivatives or synthetic substances with good binding ability in Drug discovery is known as
Replacing an ester with an amide often tends to:
A pharmacophore represents:
Lead optimization aims to improve:
How many people will be selected for phase III trial?
Compound with good activity and selectivity in screening during drug discovery is known as
A para-halogen on an aromatic ring can influence:
Ligand-based drug design can exploit:
Aspirin is introduced by_________in 1889
If a substituent increases potency but also increases lipophilicity markedly, the key concern is:
Identification of a new chemical entity as a potential therapeutic agent (From Hit to Lead) is known as
Reducing conformational flexibility can sometimes:
High-throughput screening is used to:
A lead has good target affinity but severe hERG liability. Medicinal chemistry should prioritize:
The process of bringing a new pharmaceutical drug to the market once the lead compound has been identified through the process of drug discovery. (From Lead to NDA) is known as
A structure-based design strategy uses:
A ligand binds well but is poorly soluble. A rational first strategy is:
A lead compound is best described as:
Single ascending dose studies are done in_____
A compound is active in vitro but inactive in vivo. One possible reason is:
Medicinal chemistry is interdisciplinary because it combines:
Phase IV trial is also known-
Replacing a phenyl ring with a pyridyl ring most directly changes:
Bioisosterism is used to:
A stereocenter can affect activity because:
Morphine was isolated from opium by-
A lead series shows a consistent activity trend with para-substituent changes. This can support:
The main goals of pre-clinical studies
A narrow therapeutic index increases the importance of:
Two analogues have equal potency, but one has much better selectivity. The preferred lead is generally:
A bioisosteric replacement is most useful when:
Which of the following reactions is catalyzed by the enzyme adenylate cyclase?
Precision Medicine is an emerging approach depending on-
Quaternization of an amine generally:
A carboxylic acid group in many NSAIDs commonly provides:
Medicinal chemistry is primarily concerned with:
Who is founder of modern medicine?
A compound loses potency after replacing an aromatic ring with a saturated ring. The most likely interpretation is:
A target structure reveals an unoccupied lipophilic pocket. A rational modification is:
A compound with high potency but poor oral exposure needs optimization of:
In a classical pharmacophore, a basic nitrogen may represent:
A compound is rapidly oxidized at a benzylic position. A medicinal chemist may:
How many people will be selected for phase II trial?
Adding a methyl group near a metabolic oxidation site may:
How many people will be selected for phase I trial?
