The drug that can directly release histamine from mast cells without involving antigen-antibody reaction is:
The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that:
Benefit afforded by certain H1 antihistaminics in the following condition is not based on antagonism of histamine:
Prostaglandins play pathophysiological role in the following except:
Fexofenadine differs from terfenadine in that:
Prophylactic therapy of migraine:
High anticholinergic property is present in the following antihistaminic:
The most important risk in the use of sumatriptan for treatment of migraine is:
The ‘amine’ ergot alkaloid differs from ‘amino acid’ ergot alkaloid in that it has:
Select the H1 antihistaminic which is used topically in the nose for allergic rhinitis:
The following 5-HT receptor is not a G protein coupled receptor:
The following biogenic amine is not actively taken up into its storage site by an active amine pump:
The following is a selective 5-HT1D receptor agonist:
Select the correct statement in relation to drug therapy of migraine:
Blockade of both dopamine D2 and serotonin 5-HT2A/2C receptors is a distinctive feature of:
Actions of 5-HT2 receptor activation are primarily mediated by:
Choose the correct statement about sumatriptan:
Tachyphylaxis to many actions on repeated injection is a feature of the following autacoid:
The following eicosanoid is generated through the lipoxygenase pathway:
The smooth muscle stimulating action of 5-HT is most marked in the:
The prostanoid that consistently constricts blood vessels is:
H1 antihistaminics are beneficial in:
Dihydroergotamine (DHE) differs from ergotamine in the following respect:
Which of the following is a selective H1 receptor agonist:
The nonsteroidal antiinflammatory drugs are more effective in migraine:
The conventional H1 anti-histaminics possess the following additional properties except:
1Blockade of both dopamine D2 and serotonin 5-HT2A/2C receptors is a distinctive feature of:
Histamine exerts the following actions except:
5-HT appears to play a role in the following except:
Autacoids differ from hormones in that:
The following 5-HT receptor is not a G protein coupled receptor:
The following serotonergic receptor functions primarily as an autoreceptor on neurones:
