The following receptor has an intrinsic ion channel:
Which of the following drugs exhibits ‘therapeutic window’ phenomenon:
Agonist induced autophosphorylation, internalization and down regulation is a distinctive feature of:
The therapeutic index of a drug is a measure of its:
Select the receptor that is located intracellularly:
Higher efficacy of a drug necessarily confers:
Agonists affect the receptor molecule in the following manner:
The elderly patients are relatively intolerant to:
Drug cumulation is the basis of organ toxicity of the following drug when used for prolonged periods:
The antidotal action of sodium nitrite in cyanide poison ing is based on:
The antagonism between adrenaline and histamine is called ‘physiological antagonism’ because:
If the dose-response curves of a drug for producing different actions are widely separated on the dose axis, the drug is:
Receptors perform the following function/functions:
Which of the following is true of ‘placebos’:
The following statement is true in relation to ‘drug toxicity’ and ‘poisoning’:
The receptor transduction mechanism with the fastest time-course of response effectuation is:
In congestive heart failure patients:
Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy:
‘Drug efficacy’ refers to:
Which racial difference in response to drugs has been mentioned incorrectly below:
An undesirable effect of a drug that occurs at thera peutic doses and can be predicted from its pharma cological actions is called:
In patients of hepatic cirrhosis:
A drug which does not produce any action by itself but decreases the slope of the log dose-response curve and suppresses the maximal response to another drug is a:
A drug ‘R’ producing no response by itself causes the log dose-response curve of another drug ‘S’ to shift to the right in a parallel manner without decreasing the maximal response: Drug ‘R’ is a:
A receptor which itself has enzymatic property is:
Fixed dose combination formulations are not necessarily appropriate for:
Interindividual variations in equieffective doses of a drug are most marked if it is disposed by:
All of the following subserve as intracellular second messengers in receptor mediated signal transduction except:
The following statement is not true of ‘potency’ of a drug:
The following is not a feature of competitive antagonists:
