Welcome to your Introduction, History and development of medicinal chemistry-(201)
A carboxylic acid group in many NSAIDs commonly provides:
A lead compound is best described as:
Replacing an ester with an amide often tends to:
Medicinal chemistry is interdisciplinary because it combines:
Natural products or derivatives or synthetic substances with good binding ability in Drug discovery is known as
Ligand-based drug design can exploit:
How many people will be selected for phase III trial?
Single ascending dose studies are done in_____
A compound is active in vitro but inactive in vivo. One possible reason is:
A compound is rapidly oxidized at a benzylic position. A medicinal chemist may:
In a classical pharmacophore, a basic nitrogen may represent:
A structure-based design strategy uses:
Compound with good activity and selectivity in screening during drug discovery is known as
A target structure reveals an unoccupied lipophilic pocket. A rational modification is:
Reducing conformational flexibility can sometimes:
Morphine was isolated from opium by-
Quaternization of an amine generally:
A bioisosteric replacement is most useful when:
A stereocenter can affect activity because:
Two analogues have equal potency, but one has much better selectivity. The preferred lead is generally:
A narrow therapeutic index increases the importance of:
Aspirin is introduced by_________in 1889
If a substituent increases potency but also increases lipophilicity markedly, the key concern is:
A pharmacophore represents:
A compound loses potency after replacing an aromatic ring with a saturated ring. The most likely interpretation is:
Lead optimization aims to improve:
A lead series shows a consistent activity trend with para-substituent changes. This can support:
A lead has good target affinity but severe hERG liability. Medicinal chemistry should prioritize:
Medicinal chemistry is primarily concerned with:
Bioisosterism is used to:
Replacing a phenyl ring with a pyridyl ring most directly changes:
Precision Medicine is an emerging approach depending on-
A para-halogen on an aromatic ring can influence:
How many people will be selected for phase II trial?
Human micro dosing studies conducted in which clinical phase ?
High-throughput screening is used to:
The main goals of pre-clinical studies
A ligand binds well but is poorly soluble. A rational first strategy is:
Adding a methyl group near a metabolic oxidation site may:
The process of bringing a new pharmaceutical drug to the market once the lead compound has been identified through the process of drug discovery. (From Lead to NDA) is known as
First hormone epinephrine was synthesized in Year
Who is founder of modern medicine?
A compound with high potency but poor oral exposure needs optimization of:
Which of the following reactions is catalyzed by the enzyme adenylate cyclase?
How many people will be selected for phase I trial?
Identification of a new chemical entity as a potential therapeutic agent (From Hit to Lead) is known as
Phase IV trial is also known-
